Metabolomic Tricorder Project

Socioeconomic cost of diseases

Summary:

Total incidence: 10,700,142

Total cost of treatment: $76.603 billion

Total cost to society: $168.103 billion

Overall cost: $244.703 billion

Disease	Number of new cases per year	Number (%) of Canadians living with disease	Cost of treatment (million $)	Cost to society (million $)
Alzheimer's disease	60,000³	280,000 (0.74%)³	$431³	$1,002³
Parkinson's disease	5,500⁴	100,000 (0.31%)³	$201³	$244³
Stroke	50,000³	300,000 (1%)⁵	$665³	$2,100³
Heart disease	1,200,000⁶	1,600,000 (5%)⁷	$6,818⁸	$11,654⁸
Asthma	138,000⁹	2,744,000 (8%)¹⁰	$705¹⁰	$840¹⁰
Diabetes	60,000¹¹	1,700,000 (5.3%)¹¹	$2,441¹²	$9,212¹²
Pre-eclampsia	9,600^{a, 13}	9,600 (8%)^{b, 13}	$230^{k, 42}	TBA
Pneumonia	563,200^{a, 14}	563,200 (1.76%)^{a, 14}	$840^{k, 43}	$10,100⁴⁴
Depression	1,600,000¹⁵	1,700,000 (5.3%)^{a, 14}	$3,270^{m,n, 48}	$51,000⁴⁹
Autism	2,625^{l, 16,47}	217,600 (0.68%)^{a, 16}	$1,365^{n,o, 50}	$8,275^{n,o, 50}
Urinary tract infections	1,026,984^{a, 17}	1,026,984 (3.21%)^{a, 17}	$84^{n, 51}	$140^{n, 51}
Atherosclerosis	112,000^{a, 18}	544,000 (1.7%)^{a, 14}	$19,800^{n,m,p, 52}	$13,494^{n,m,p, 52}
COPD	89,600^{c, 19}	772,200 (2.41%)⁴⁶	$1,544⁴⁷	$772⁴⁷
Multiple Sclerosis	1,026^{a, 20}	44,800 (0.14%)^{a, 14}	$277^{n, 53}	$789^{n, 53}
Osteoarthritis	320,000^{a, 21}	2,352,000 (7.35%)^{a, 14}	$6,115⁵⁴	$7,291⁵⁴
Chronic kidney disease	300,800^{a, 14}	270,400 (2.72%)^{a, 14}	$9,180⁵⁵	N/A
Schizophrenia	10,240^{a, 22}	259,200 (0.81%)^{a, 14}	$1,637^{n, 57}	$1,798^{n, 57}
Rheumatoid arthritis	9,600^{a, 23}	294,400 (0.92%)^{a, 14}	$1,834^{n,r, 56}	$822^{n,r, 56}
Lung cancer	25,600³⁵	39,884 (0.12%)³⁸	$163^{n,s, 2}	$769^{n,s, 2}
Prostate cancer	25,500³⁷	150,135 (0.47%)³⁸	$1033^{n,s, 2}	$4860^{n,s, 2}
Pancreatic cancer	3,977³⁸	3,452 (0.11%)³⁸	$15^{n,s, 2}	$72^{n,s, 2}
Breast cancer	23,590³⁹	153,777 (0.48%)³⁸	$1161^{n,s, 2}	$5460^{n,s, 2}
Esophageal cancer	1,586³⁸	2,419 (0.01%)³⁸	$10^{n,s, 2}	$47^{n,s, 2}
Colorectal cancer	20,599^{h, 38}	99,819 (0.31%)³⁸	$426^{n,s, 2}	$2005^{n,s, 2}
Liver cancer	1,586³⁸	2,490 (0.01%)³⁸	$10^{n,s, 2}	$50^{n,s, 2}
Lymphoma	7,703^{i, 38}	39,654 (0.12%)^{i, 38}	$169^{n,s, 2}	$796^{n,s, 2}
Brain cancer	2,581³⁸	6,214 (0.02%)³⁸	$26^{n,s, 2}	$124^{n,s, 2}
Multiple myeloma	1,991³⁸	6,645 (0.02%)³⁸	28^{n,s, 2}	134^{n,s, 2}
Bladder cancer	6,754³⁸	37,216 (0.12%)³⁸	159^{n,s, 2}	747^{n,s, 2}
Bone cancer	354³⁸	4085 (0.01%)^{a, 36}	17^{n,s, 2}	82^{n,s, 2}
Cervical cancer	1,401³⁸	9,806 (0.03%)³⁸	42^{n,s, 2}	197^{n,s, 2}
Leukemia	5,000³⁸	19666 (0.06%)³⁸	$84^{n,s, 2}	$395^{n,s, 2}
Amyotrophic lateral sclerosis	640^{a, 23}	3,080 (0.1%)^{a, 23}	$17^{n, 61}	$218^{n, 61}
Epilepsy	22,400^{a, 14}	272,000 (0.85%)^{a, 14}	$129^{n, 61}	$904^{n, 61}
Osteoporosis	176,000^{a,d, 14}	3,292,800 (10.29%)^{a, 14}	$1,525^{t,v, 62}	$99^{t,v, 62}
Alcoholism	88,800^{a,e, 14}	1,776,000 (5.55%)^{a, 14}	$4,671^{n,t, 63}	$10,070^{n,t, 63}
Hypertension	576,000²⁶	5,881,600 (18.38%)^{a, 14}	$5,615^{k,n,t,u, 64}	$1,977^{k,n,t,u, 64}
Attention Deficit Hyperactivity Disorder	191,304^{a, 27}	387,200 (1.21%)^{a, 14}	$1,198^{k,n,u, 65}	$5,430^{k,n,u, 65}
Periodontal disease	662,400^{a, 14}	2,726,400 (8.52%)^{a, 28}	$1,767^{k,n,t,u, 67}	N/A
Gout	19,936^{a, 29}	89,600 (0.28%)^{a, 14}	$372^{n, 66}	N/A
Heart Failure	48,000^{a, 14}	563,200 (1.28%)^{a, 14}	$3,692	$4,124
Celiac disease	9,600^{a, 30}	128,000 (0.4%)^{a, 14}	$3^{w, 70}	$90^{x, 70}
Crohn's disease	2,240^{a, 31}	57,600 (0.18%)^{a, 14}	$556^{n, 71}	$633^{n, 71}
Ulcerative Colitis	2,240^{a, 32}	32,000 (0.10%)^{a, 14}	$246^{n, 71}	$499^{n, 71}
Inflammatory Bowel Disease	4,480^{a, 31,32}	89,600 (0.28%)^{a, 14}	$802^{n,y, 71}	$1,132^{n,y, 71}
Neural tube defects	320⁴¹	18,000 (0.06%)^{j, 41}	$89^{n,u,z, 72}	$114^{n,u,z, 72}
Hepatitis A	484^{t, 73}	484 (0.001%)^{t, 73}	$1^{n,t, 73}	$1^{n,t, 73}
Septicemia (severe)	104,100^{a,t, 74}	104,100(0.3%)^{a,t, 74}	$4,434^{n, 74,75}	$10,348^{n, 74,75}
Lupus	1,792^{a, 33}	163,200 (0.51%)^{a, 14}	$2,198^{k,n, 76}	$1,505^{k,n, 76}
Addison's Disease	16^{a,e 14}	320 (0.001%)^{a, 14}	$1^{k,n, 76}	N/A
Cancer Cachexia	88,900^{f, 34}	355,000 (1.13%)^{f, 34}	N/A	N/A
Chronic hepatitis	544,000^{a,g, 14}	972,800 (3.04%)^{a, 14}	$141^{k,n,t,aa, 77}	$229^{k,n,t,aa, 77}
Bronchitis	1,472,000^{a, 14}	1,472,000 (4.45%)^{a, 14}	$220^{k,n,t, 78}	$3^{k,n,t, 78}
Tuberculosis (new and relapsed)	1,856⁴⁰	1,856 (0.006%)⁴⁰	$96^{n, 79}	$8^{n, 80}
Peptic ulcer	435,200^{a, 14}	588,800 (1.84%)^{a, 14}	$445^{k,n,t,u, 81}	$271^{k,n,t,u, 81}
Chronic fatigue syndrome	118,400^{t, 58}	588,800 (1.84%)^{t, 59}	$381^{u, 60}	$2,025^{u, 60}
Fibromyalgia	315,729^{t, 68}	1,147,476 (3.33%)^{t, 68}	$5,667^{n, 69}	$1,070^{n, 69}
Bipolar disorder	3,570^{t, 82}	564,000 (1.6%)^{t, 83}	$1,541^{n, 84}	$6,670^{n, 84}
Gall bladder disease	151,639⁸⁵	2,450,000 (1.6%)^{a,t, 86}	$432^{n,t,u, 87}	$23^{n,t,u, 87}
Appendicitis	86,875^{t, 14}	86,875 (0.25%)^{t, 14}	$187^{n,t,u, 88}	$12^{n,t,u, 88}

TBA - to be added, N/A - not available
^a - the prevalance and incidence for Canada were recalcualted from US or worldwide statistics.
^b - the prevalance of the pre-eclampsia was calculated for the total number of pregnancies instead of general population.
^c - the prevalance and incidence for Canada were recalcualted from Alberta province statistics.
^d - the number of osteoporosis-related fractures is reported as osteoporosis incidence
^e - incidence was estimated by dividing prevalance of this disease by 20 (years)²⁵
^f - incidence and prevalance of cancer cachexia was estimated as 50% of overall cancer incidence and prevalance, respectively³⁴
^g - general hepatitis incidence is shown
^h - combined indcidence of large intestine cancer and rectum cancer in the reference 38 is used as the incidence of colorectal cancer
ⁱ - combined statistics for Hodgkin lymphoma and non-Hodgkin lymphoma ^j - prevalance was estimated by multiplying incidence of this disease by 70 (years)²⁵
^k - disease cost for Canada was recalcualted from US or worldwide statistics
^l - authism incidence was estimated by multiplying the number of birth in Canada²⁵ by the authism frequency in Canada¹⁶
^m - the global disease cost for Canada in 2012 was estimated by dividing the global disease cost for US by 10
ⁿ - the disease cost was corrected for inflation using CPI Inflation Calculator
^o - the disease cost for Canada was estimated from the disease cost for Australia by adjusting it according to the difference in Canada and Australia population
^p - the cost of atherosclerotic cardiovascular diseases (stroke, coronary heart disease, myocardial infarction, congestive heart failure) is shown
^r - the disease cost for Canada was determined multiplying the single patient cost by the disease prevalance
^s - the cost of this type of cancer was calculated from its prevalance and the cost and prevalance of all cancer cases²
^t - the statistic was adjusted to be consistent with Canada population in 2012
^u - 1:1 ratio between USD and CAD was assumed
^v - Calculation of direct cost of osteoporosis assumed that direct medical cost of osteoporosis-related fractures in women is two times that of men⁶²
^w - The annual cost of diagnostic is shown as the direct cost
^x - The difference between the cost of gluten-free food and regular food is shown as the indirect cost
^y - The cost of the Inflammatory Bowel Disease was calcuated by cobining the cost of Crohn's Disease and ulcerative colitis
^z - The annual cost was calculated with the following formula Cost=Prevalence*(Lifetime_Per_Patient_Cost/(Prevalence/Incidence))
^aa - Cost of chronic hepatitis C is shown.

Socioeconomic cost of diseases

References